Imuran

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Imuran side effects weight gain

I was recently admitted to hospital after visiting my GP with persistant stomach imuran side effects weight gain pain (about 2 months on and off) and to cut a long story short, a CT scan showed an inflamed bowel which I was told was most likely down to Crohns diesese. I ened up having a small section of bowel removed by the surgeon, and am now back imuran side effects weight gain to normal -.g. No pain or discomfort imuran side effects weight gain what so ever, eating and drinking normally, normal bowel movements. In fact you'd never know I had been ill! Now on a follow up at the hospital I have been prescribed Azathioprine tablets. I was given a 30 minute pep-talk by a pharmacist explaining the drug, which if I'm honest terrified. Risk of cancer, nausea, feeling unwell, reduced bone marrow etc. In fact, lots of very unpleasant side effects. Basically, I feel great right now; 100, and it sounds like these tablets will make me feel 'not great.' I want to talk to the consultant before I start taking them, but cant get appt until April. From reading posts on the forum, and some general research, it sounds like Azathioprine is used to control inflamation during flare ups, or treat chronic Crohns that is affecting quality of life? Yet I have no symptoms, no pain or discomfort, and feel great. I appreciate that Azathioprine can also be used to prevent Crohns from coming back again, but with all the associated risks, and I gather you can only take it for a total of around five years before it stops working, is now the right time. Should it not be held in reserve in case I have problems in the future? Yes, I will be guided by my doctor, but until I can get to see him, I just wanted to get some feedback from anyone else on here using Azathioprine. Has anyone been in my position and started taking it? Sorry if I sound like an idiot - I'm feeling very confused and a little concerned about this drug. Do I really want to take something that will make me feel worse than I do now, and possibly even give me cancer? Any feedback greatfully received! Note: This document contains side effect information about azathioprine. Some of the dosage imuran side effects weight gain forms listed on this page may not apply to the brand name Imuran. Common side effects of Imuran include: infection, leukopenia, and vomiting. See below for a comprehensive list of adverse effects. Along with its needed effects, azathioprine (the active ingredient contained. Imuran ) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur imuran side effects weight gain they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking azathioprine: Some side effects of azathioprine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to azathioprine: compounding powder, intravenous powder for injection, oral tablet. The principal and potentially serious toxic effects of azathioprine (the active ingredient contained in Imuran) are hematologic and gastrointestinal. Risk of secondary infection and malignancy is also significant. Frequency and severity of side effects depend on dose and duration of azathioprine as well as on underlying disease or concomitant therapies. Hematologic toxicities and neoplasia were reported more often in renal homograft recipients than in patients using azathioprine for rheumatoid arthritis. Ref, very common (10 or more Depression of bone marrow function, leukopenia, common (1 to 10 Anemia, thrombocytopenia. Rare (Less than.1 Agranulocytosis, aplastic anemia, erythroid hypoplasia, megaloblastic anemia, pancytopenia, frequency not reported: Bleeding, increased mean corpuscular volume and red cell hemoglobin content (reversible, dose-related). Ref, bone marrow suppression is dose related and is the most common cause for dosage reductions. Leukopenia (any degree) has been reported in greater than 50 of renal homograft recipients and 28 of rheumatoid arthritis patients. Leukopenia (less than 2500/mm3.5 x 10(9 L) has been reported in 16 of renal homograft recipients and.3 of rheumatoid arthritis patients. There are data to support an increased risk of bone marrow aplasia in patients with very low or absent thiopurine methyltransferase (tpmt) activity.

Imuran azathioprine 50 mg

Skip to main content, start typing to retrieve search suggestions. When imuran azathioprine 50 mg suggestions are available use up and down arrows to review and enter to select. Continue typing to refine. Advanced Search Back to top, active imuran azathioprine 50 mg ingredient azathioprine. Legal Category, pOM: Prescription only medicine, this information is intended for use by health professionals. Name of the medicinal product. Imuran Tablets 50mg. Qualitative and quantitative composition, yellow, round, biconvex, scored, film-coated tablets, impressed 'GX CH1' and containing 50 mg Azathioprine BP in each tablet. Clinical particulars.1 Therapeutic indications. Imuran tablets are used as an immunosuppressant antimetabolite either alone or, more commonly, in combination with other agents (usually corticosteroids) and procedures which influence the immune response. Therapeutic effect may be evident only after weeks or months and can include a steroid-sparing effect, thereby reducing the toxicity associated with high dosage and prolonged usage of corticosteroids. Imuran, in combination with corticosteroids and/or other immunosuppressive agents and procedures, is indicated to enhance the survival of organ transplants, such as renal transplants, cardiac transplants, and hepatic transplants; and to reduce the corticosteroid requirements of renal transplant recipients. Imuran, either alone or more usually in combination with corticosteroids and/or other drugs and procedures, has been used with clinical benefit (which may include reduction of dosage or discontinuation of corticosteroids) in a proportion of patients suffering from the following: Severe rheumatoid arthritis; Systemic lupus. 4.2 Posology and method of administration. Route of administration: oral. Transplantation - adults and children, depending on the immunosuppressive regimen employed, a dosage of up to 5 mg/kg bodyweight/day may be given on the first day of therapy, either orally or intravenously. Maintenance dosage should range from 1 to 4 imuran azathioprine 50 mg mg/kg bodyweight/day and must be adjusted according to clinical requirements and haematological tolerance. Evidence indicates that Imuran therapy should be maintained indefinitely, even if only low doses are necessary, because of the risk of graft rejection. Dosage in other conditions - adults and children. In general, starting dosage is from 1 to 3 mg/kg bodyweight/day, and should be adjusted, within these limits, depending on the clinical response (which may not be evident for weeks or months) and haematological tolerance. When therapeutic response is evident, consideration imuran azathioprine 50 mg should be given to reducing the maintenance dosage to the lowest level compatible with the maintenance of that response. If no improvement occurs in the patient's condition within 3 months, consideration should be given to withdrawing Imuran. The maintenance dosage required may range from less than 1 mg/kg bodyweight/day to 3 mg/kg bodyweight/day, depending on the clinical condition being treated and the individual patient response, including haematological tolerance. In patients with renal and/or hepatic insufficiency, dosages should be given at the lower end of the normal range (see Special Warnings and Precautions for Use for further details). Use in the elderly (see Renal and/or hepatic insufficiency). There is limited experience of the administration of Imuran to elderly patients. Although the available data do not provide evidence that the incidence of side effects among elderly patients is higher than that among other patients treated with Imuran, it is recommended that the dosages used should be at the lower end of the range. Particular care should be taken to monitor haematological response and to reduce the maintenance dosage to the minimum required for clinical response. Patients with nudt15 variant, patients with inherited mutated nudt15 gene are at increased risk for severe azathioprine toxicity (see ese patients generally require dose reduction; particularly those being nudt15 variant homozygotes (see.4). Genotypic testing of nudt15 variants may be considered before initiating azathioprine therapy. In any case, close monitoring of blood counts is necessary. 4.3 Contraindications, imuran is contra-indicated in patients known to be hypersensitive to azathioprine. Hypersensitivity to 6-mercaptopurine (6-MP) should alert the prescriber to probable hypersensitivity to Imuran. Imuran therapy should not be initiated in patients who may be pregnant, or who are likely to become pregnant without careful assessment of risk versus benefit (see Special Warnings and Precautions for Use Pregnancy and Lactation). 4.4 Special warnings and precautions for use.

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